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Rapid Detection of Wheat Blast Pathogen Magnaporthe Oryzae Triticum Pathotype Using Genome-SpecificPrimers and Cas12a-mediated Technology Article

Houxiang Kang, Ye Peng, Kangyu Hua, Yufei Deng, Maria Bellizzi, Dipali Rani Gupta, Nur Uddin Mahmud, Alfredo S. Urashima, Sanjoy Kumar Paul, Gary Peterson, Yilin Zhou, Xueping Zhou, Md Tofazzal Islam, Guo-Liang Wang

Engineering 2021, Volume 7, Issue 9,   Pages 1326-1335 doi: 10.1016/j.eng.2020.07.016

Abstract:

Wheat blast, caused by the fungus Magnaporthe oryzae Triticum (MoT) pathotypeFollowing this, we used the Cas12a protein and guide RNAs (gRNAs) to target the MoT-6098 and MoT-6099The activated Cas12a showed indiscriminate single-stranded DNase (ssDNAase) activity.We then combined target-dependent Cas12a ssDNase activation with recombinase polymerase amplification

Keywords： Wheat blast     Magnaporthe oryzae     Triticum Cas12a     Nucleic acid rapid lateral flow immunoassay     Field    

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Mobile CRISPR-Cas9 based anti-phage system in E. coli

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 8,   Pages 1281-1289 doi: 10.1007/s11705-022-2141-7

Abstract: Here, we developed a mobile CRISPR-Cas9 based anti-phage system for bacteriophages defense in E. coli

Keywords： phage infections     anti-phage     CRISPR-Cas9     conjugative transfer     synthetic biology    

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Advances of 12th CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3,   Pages 461-463 doi: 10.1007/s11705-020-2026-6

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Introduction to the special section on the 12

Zhen-Min CHENG

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 1,   Pages 1-1 doi: 10.1007/s11705-009-0003-1

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PAM-Expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G Base Editors for Programmable Base Editing Article

Hongyuan Zhang, Yifei Zhang, Wei-Xiao Wang, Weizhong Chen, Xia Zhang, Xingxu Huang, Wei Chen, Quanjiang Ji

Engineering 2022, Volume 15, Issue 8,   Pages 67-77 doi: 10.1016/j.eng.2022.02.013

Abstract: discovered that only the unusual Streptococcus thermophilus CRISPR associated protein 9 (St1Cas9) cytosine base editor (CBE)—but not the widely used Streptococcus pyogenes Cas9 (SpCas9Despite the notable C-to-T conversions, a high proportion of undesired byproducts exists with St1Cas9We therefore engineered St1Cas9 CBE by means of uracil DNA glycosylase inhibitor (UGI) or uracil DNABecause wild-type St1Cas9 recognizes a relatively strict protospacer adjacent motif (PAM) sequence for

Keywords： CRISPR     Cas9     Mycobacterium tuberculosis     Genome editing     Base editing    

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ThMn12-Type Alloys for Permanent Magnets Review

G.C. Hadjipanayis, A.M. Gabay, A.M. Schönhöbel, A. Martín-Cid, J.M. Barandiaran, D. Niarchos

Engineering 2020, Volume 6, Issue 2,   Pages 140-146 doi: 10.1016/j.eng.2018.12.011

Abstract:

Iron-rich compounds with the tetragonal ThMn12-type structure have the potential to meetdevelopment of underlying magnetic material, this gap has always been unusually large for ThMn12A controlled crystallization of the initially suppressed ThMn12-type phase makes "bulkSm-Fe-V alloys (in which it has been known since the 1990s), but also is in La-added (Ce,Sm)(Fe,Ti)12Mechanochemically synthesized (Sm,Zr)(Fe,Si)12 and (Sm,Zr)(Fe,Co,Ti)12 powders

Keywords： Permanent magnets     Rare earths permanent magnets     ThMn12 structure    

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CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 554-562 doi: 10.1007/s11684-017-0543-6

Abstract: successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using CRISPR-Cas9

Keywords： CAR-T     CRISPR-Cas9     LAG-3    

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Generation of CRISPR/Cas9-mediated lactoferrin-targeted mice by pronuclear injection of plasmid pX330

Mengxu GE,Fei LIU,Fei CHANG,Zhaolin SUN,Jing FEI,Ying GUO,Yunping DAI,Zhengquan YU,Yaofeng ZHAO,Ning LI,Qingyong MENG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3,   Pages 242-248 doi: 10.15302/J-FASE-2015059

Abstract: functions and mechanisms of lactoferrin, we modified the lactoferrin promoter of mice using the CRISPR/Cas9

Keywords： lactoferrin     promoter     CRISPR/Cas9     plasmid pX330    

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Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 83-93 doi: 10.1007/s11684-019-0682-z

Abstract: EGFR accelerate the growth of CRC cells in vitro and in vivo and monoclonal antibody CH12Furthermore, mAb CH12 showed significantly stronger growth suppression activities and induced a moreantibody-dependent cellular cytotoxicity effect on CRC cells bearing S492R EGFR than mAb C225. mAb CH12Thus, mAb CH12 may be a promising therapeutic agent in treating patients with CRC bearing an S492R EGFR

Keywords： S492R EGFR ectodomain mutation     colorectal cancer     mAb CH12     immunnotherapy    

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WHEAT STRIPE RUST AND INTEGRATION OF SUSTAINABLE CONTROL STRATEGIES IN CHINA

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 37-51 doi: 10.15302/J-FASE-2021405

Abstract:

Stripe (yellow) rust caused by Puccinia striiformis f. sp. tritici occurs in almost all wheat-producing regions of the world. Severe countrywide epidemics in China have caused substantial yield losses. Growing resistant cultivars is the best strategy to control this disease but the pathogen can overcome resistance in wheat cultivars. The high variation in the virulence of the pathogen combined with the large areas of susceptible wheat cultivars enables the pathogen population to increase rapidly and disperse over long distances under favorable environmental conditions, resulting in severe pandemics within cropping seasons. Current stripe rust control measures are based on many years of research including the underlying epidemiology regarding year-to-year survival of the pathogen, pathways of pathogen dispersal within seasons and years, the role of P. striiformis sexual hybridization, the use of resistance sources in breeding programs, and year-round surveillance of national wheat crops that are present in different parts of the country throughout the year. All these strategies depend on accurate prediction of epidemics, more precise use of fungicides to meet national requirements and better deployment of resistance genes. New ideas with potential application in sustainable protection of stripe rust include negative regulatory gene editing, resistance gene overexpression and biological control based on microbiomes.

 

Keywords： sustainable disease control / integrated control Puccinia striiformis / Triticum aestivum    

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Progress and Prospect of Semiconductor Silicon Wafers in China

Zhang Guohu, Xiao Qinghua, Ma Fei

Strategic Study of CAE 2023, Volume 25, Issue 1,   Pages 68-78 doi: 10.15302/J-SSCAE-2023.01.002

Abstract: This study focuses on the market-dominant 8-inch and 12-inch silicon wafers, analyzes the development

Keywords： semiconductor silicon wafer     8 inches     12 inches     industry synergy     advanced processing    

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Leader-following synchronization of a multi-agent system with heterogeneous delays Research Articles

Branislav Rehák, Volodymyr Lynnyk,rehakb@utia.cas.cz,volodymyr.lynnyk@utia.cas.cz

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 1,   Pages 1-140 doi: 10.1631/FITEE.2000207

Abstract: An algorithm is presented for leader-following synchronization of a composed of linear agents with . The presence of different delays in various agents can cause a synchronization error that does not converge to zero. However, the norm of this error can be bounded and this boundary is presented. The proof of the main results is formulated by means of linear matrix inequalities, and the size of this problem is independent of the number of agents. Results are illustrated through examples, highlighting the fact that the steady error is caused by heterogeneous delays and demonstrating the capability of the proposed algorithm to achieve synchronization up to a certain error.

Keywords： Multi-agent system     Time delay     Linear matrix inequality    

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Facile controlled synthesis of hierarchically structured mesoporous Li4Ti5O12/C/rGO composites as high-performance

Cehuang FU, Shuiyun SHEN, Ruofei WU, Xiaohui YAN, Guofeng XIA, Junliang ZHANG

Frontiers in Energy 2022, Volume 16, Issue 4,   Pages 607-612 doi: 10.1007/s11708-021-0798-0

Abstract: facile strategy is proposed to controllably synthesize mesoporous Li4Ti5O12graphene matrix as lithium-ion battery anode via the co-assembly of Li4Ti5O12

Keywords： Li4Ti5O12     phenolic-resin-based carbon     mesoporous composite     graphene    

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Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

Yang Sun,Chenze Li,Lina Zhang,Dong Hu,Xudong Zhang,Ting Yu,Min Tao,Dao Wen Wang,Xiaoqing Shen

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 53-61 doi: 10.1007/s11684-017-0502-2

Abstract: All patients were followed up at the 1st, 6th, and 12th month of discharge while recording ATM and majorcoronary artery bypass grafting (CABG) alone had significantly lower proportion of high adherence to P2Y12Moreover, in patients undergoing PCI, high adherence to P2Y12 antagonists decreased the risk of MACEHigh adherence to P2Y12 antagonists was associated with lower risk of MACE.

Keywords： acute coronary syndromes     adherence to secondary prevention medications     clinical outcome    

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AC-DC Power Integration Techniques

Ma Weiming

Strategic Study of CAE 2002, Volume 4, Issue 12,   Pages 53-59

Abstract: electric power integration, wherein the stator with one set of 3-phase AC winding and another set of 12together with a rotor having a d-axis field winding and a q-axis stabilizing winding, is combined with a 12Due to complete electrical separation of the AC and DC circuits and usage of the properly designed 12The principle and methods for on-line real time fault diagnosis of the diodes in the 12-phase rectifier

Keywords： electric power integration     double-winding AC - DC generator     12-phase rectification     simultaneous AC and    

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Title Author Date Type Operation

Rapid Detection of Wheat Blast Pathogen Magnaporthe Oryzae Triticum Pathotype Using Genome-SpecificPrimers and Cas12a-mediated Technology

Houxiang Kang, Ye Peng, Kangyu Hua, Yufei Deng, Maria Bellizzi, Dipali Rani Gupta, Nur Uddin Mahmud, Alfredo S. Urashima, Sanjoy Kumar Paul, Gary Peterson, Yilin Zhou, Xueping Zhou, Md Tofazzal Islam, Guo-Liang Wang

Journal Article

Mobile CRISPR-Cas9 based anti-phage system in E. coli

Journal Article

Advances of 12th CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

Journal Article

Introduction to the special section on the 12

Zhen-Min CHENG

Journal Article

PAM-Expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G Base Editors for Programmable Base Editing

Hongyuan Zhang, Yifei Zhang, Wei-Xiao Wang, Weizhong Chen, Xia Zhang, Xingxu Huang, Wei Chen, Quanjiang Ji

Journal Article

ThMn12-Type Alloys for Permanent Magnets

G.C. Hadjipanayis, A.M. Gabay, A.M. Schönhöbel, A. Martín-Cid, J.M. Barandiaran, D. Niarchos

Journal Article

CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Journal Article

Generation of CRISPR/Cas9-mediated lactoferrin-targeted mice by pronuclear injection of plasmid pX330

Mengxu GE,Fei LIU,Fei CHANG,Zhaolin SUN,Jing FEI,Ying GUO,Yunping DAI,Zhengquan YU,Yaofeng ZHAO,Ning LI,Qingyong MENG

Journal Article

Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Journal Article

WHEAT STRIPE RUST AND INTEGRATION OF SUSTAINABLE CONTROL STRATEGIES IN CHINA

Journal Article

Progress and Prospect of Semiconductor Silicon Wafers in China

Zhang Guohu, Xiao Qinghua, Ma Fei

Journal Article

Leader-following synchronization of a multi-agent system with heterogeneous delays

Branislav Rehák, Volodymyr Lynnyk,rehakb@utia.cas.cz,volodymyr.lynnyk@utia.cas.cz

Journal Article

Facile controlled synthesis of hierarchically structured mesoporous Li4Ti5O12/C/rGO composites as high-performance

Cehuang FU, Shuiyun SHEN, Ruofei WU, Xiaohui YAN, Guofeng XIA, Junliang ZHANG

Journal Article

Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

Yang Sun,Chenze Li,Lina Zhang,Dong Hu,Xudong Zhang,Ting Yu,Min Tao,Dao Wen Wang,Xiaoqing Shen

Journal Article

AC-DC Power Integration Techniques

Ma Weiming

Journal Article